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Pregnancy · 2 min read

GLP-1s and breastfeeding: what's known so far

Can you take Wegovy, Ozempic or Zepbound while breastfeeding? Here is what the labels say, what is unknown, and how to plan with your care team.

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Sourced from FDA labels and professional guidelinesChecked by the evenwell team, not a clinician · Updated

Key points

After a baby, many women are eager to get back on track. If you’re breastfeeding, here’s what to know first.

What the labels say

This is one place where “there’s no data” has stopped being the whole answer, and the three labels now say different things.

MedicineWhat its label says about human milk
Zepbound (tirzepatide)Measured. In 11 healthy breastfeeding women given a single 5 mg dose, tirzepatide was undetectable in 164 of 171 milk samples
Wegovy injection (semaglutide)No data on whether the injected medicine reaches human milk
Wegovy tablets (semaglutide)Semaglutide was below the level the test could measure in human milk. But SNAC, the ingredient that helps the tablet absorb, is present in milk

All of them still say the same thing about what to do with that: weigh the benefits of breastfeeding, your own need for the medicine, and any possible effect on the baby. None of them says it is safe, and none says it is unsafe.

What’s unknown

QuestionWhat we know
Does it pass into milk?For tirzepatide, mostly no — it was undetectable in nearly every sample. For injected semaglutide, nobody has looked
Could it affect the baby?Unknown. “Not much gets into milk” is not the same as “no effect”
Could it reduce milk supply?Unknown. Eating much less could affect supply

Things to think about

A real-life example

Rosa, 36, was on Zepbound before pregnancy and wanted to restart at 3 months postpartum while still nursing. Her prescriber and pediatrician walked through the unknowns. They agreed she’d wait until she weaned at 9 months, and focused on protein, sleep and walking in the meantime.

Questions to ask

Common questions

Can I take Wegovy while breastfeeding?

There isn’t enough data. Talk to your prescriber and pediatrician before deciding.

Does Ozempic get into breast milk?

It hasn’t been well studied in humans. LactMed and your pharmacist can share the latest information.

When can I restart after weaning?

Ask your prescriber. You may need to restart at a low dose.

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If this applies to you, it's worth asking your prescriber about. evenwell doesn't replace medical advice.

Sources

verified Wegovy prescribing information, §8.2 (FDA) open_in_new verified Zepbound prescribing information, §8.2 (FDA) open_in_new verified NIH LactMed database open_in_new
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